Cuvee du Vatican is a 40-acre estate in Chateauneuf-du-Pape, in the Rhone Valley. It is owned and operated by the Diffonty family, which traces its history in Rhone Valley winemaking to the 17th century. Jean-Marc Diffonty now runs the estate. Red and white wines are produced, and the red is a traditional blend of 70% Grenache, 15% Syrah, 12% Mourvedre and 3% Cinsault. The white is a blend of Clairette, Roussane, Grenache Blanc and Bourboulenc. Nearly 6,000 cases of red are produced annually.

They have old vines. Their oldest Grenache vines date back to 1905, those are planted in the La Crau sector. 21 hectares are devoted to making red wine and 1.4 hectares are used for the production of white Chateauneuf du Pape wine.